479 Introduction of a Novel Multispectral Imaging Screening Algorithm to Distinguish Malignant Melanoma from Seborrheic Keratosis

Malignant melanoma (MM) is in the background of majority skin cancer-related mortality. On other hand, seborrheic keratosis (SK) a common benign lesion that certain cases can mimic MM. In this work, we utilized multispectral imaging device prototype with LED illumination to differentiate MM from SK, use 405 nm autofluorescence and 525 660 diffuse reflectance imaging. Intensity descriptors captured images were analyzed, including ratios, standard deviation minimum maximum intensity values lesions investigated channels. Particle analysis was performed assess characteristic patterns lesions. Significantly higher found SKs compared MMs, especially on images. addition, significantly more particles high fluorescence SK Based these results, created novel algorithm provides parameter, index, distinguish sensitivity 91.9% specificity 57.0%. our findings, may be introduced clinical practice as screening method based assessment